Women have always played an important role in the development of toxicology all over the world. Specifically in Brazil, toxicology has had greater female representation than other countries, but women's participation at high hierarchical levels is low. Although more than 62% of the members of the Brazilian Society of Toxicology are women, only 7 out of the 22 presidents have been women throughout its 48 years of existence. This article aims to celebrate women in the field of toxicology in Brazil, based on interviews with five of these scientists who have changed the field of toxicology in Brazil as we know it today, each in their specific sub-areas. These women are: Dr. Ester de Camargo Fonseca Moraes, Dr. Silvia Berlanga de Moraes Barros, Dr. Alice Aparecida da Matta Chasin, Dr. Gisela de Aragão Umbuzeiro, and Dr. Tania Marcourakis. They are not only pioneers but they are also examples of admirable persistence in fighting the adversities presented to them. They broke the glass ceiling and opened doors for future generations of women in science. We hope that this article helps inspire women in their careers in toxicology.

RESUMO: A composição e o nível de infestação de plantas daninhas interferem na produtividade das culturas e aumentam o custo de produção. Este trabalho foi realizado com o objetivo de identificar a composição e a infestação de plantas daninhas em milho cultivado com diferentes populações de plantas, solteiro e consorciado com braquiária. Utilizou-se o método fitossociológico para avaliar a densidade, frequência e dominância e o nível de infestação de plantas daninhas nos tratamentos com milho solteiro e consorciado, com espaçamento convencional (0,90 m) e reduzido (0,45 m) e com baixa e alta população de plantas, em Dourados, MS. Commelina benghalensis, Echinochloaspp. e Euphorbia heterophylla foram as espécies mais encontradas nos tratamentos. O milho solteiro com maior população de plantas diminuiu a ocorrência de plantas daninhas. Os tratamentos com braquiária, no espaçamento reduzido, apresentaram menor infestação absoluta de plantas daninhas (cerca de 75%) quando comparado ao milho solteiro. A infestação de plantas daninhas é menor no consórcio de milho com braquiária, e o efeito é mais pronunciado no espaçamento reduzido.

ABSTRACT: Composition and level of weed infestation interfere with crop yield and increase production costs. This study aimed to identify weed composition and infestation in corn grown with different plant populations, single, and intercropped with palisade grass. The phytosociological method was used to evaluate density, frequency, dominance, and infestation level of weeds in single and intercropped corn, a with conventional (0.90 m) and reduced (0.45 m) spacing, and low and high plant population in Dourados, MS, Brazil. Commelina benghalensis, Echinochloaspp., and Euphorbia heterophylla were the species most found in the treatments. Single corn with higher plant population decreased weed occurrence. Treatments with palisade grass under a reduced spacing showed lower absolute weed infestation (about 75%) when compared to single corn. Weed infestation was lower in the intercropping of corn with palisade grass, with more pronounced effect under a reduced spacing.

Previous studies have reported on the glucose and lipid-lowering effects of ferulic acid (FA) but its anti-obesity potential has not yet been firmly established. This study investigated the possible anti-obesitogenic effects of FA in mice fed a high-fat diet (HFD) for 15 weeks. To assess the antiobesity potential of FA, 32 male Swiss mice, weighing 20–25 g (n=6–8 per group) were fed a normal diet (ND) or HFD, treated orally or not with either FA (10 mg/kg) or sibutramine (10 mg/kg) for 15 weeks and at the end of this period, the body weights of animals, visceral fat accumulation, plasma levels of glucose and insulin hormone, amylase and lipase activities, the satiety hormones ghrelin and leptin, and tumor necrosis factor-α (TNF-α) and monocyte chemoattractant protein-1 (MCH-1) were analyzed. Results revealed that FA could effectively suppress the HFD-associated increase in visceral fat accumulation, adipocyte size and body weight gain, similar to sibutramine, the positive control. FA also significantly (P<0.05) decreased the HFD-induced elevations in serum lipid profiles, amylase and lipase activities, and the levels of blood glucose and insulin hormone. The markedly elevated leptin and decreased ghrelin levels seen in HFD-fed control mice were significantly (P<0.05) reversed by FA treatment, almost reaching the values seen in ND-fed mice. Furthermore, FA demonstrated significant (P<0.05) inhibition of serum levels of inflammatory mediators TNF-α, and MCH-1. These results suggest that FA could be beneficial in lowering the risk of HFD-induced obesity via modulation of enzymatic, hormonal and inflammatory responses.

O óleo essencial de erva-doce (OED) foi avaliado como alternativa aos antimicrobianos na ração de frangos de corte alojados em cama nova (CNo) e reciclada (CRe). Foram alojadas 1.050 aves, e adotou-se o delineamento inteiramente ao acaso, em que de um a 21 dias as aves foram mantidas somente em CNo, resultando em sete tratamentos com 10 repetições de 15 aves: T1= dieta controle positivo (CP) com antimicrobiano (ANT); T2= dieta controle negativo (CN) sem ANT e sem OED; T3= CN + 0,004% OED; T4= CN + 0,008% OED; T5= CN + 0,016% OED; T6= CN + 0,032% OED e T7= CN + 0,064% OED. De 22 a 42 dias, metade das aves foram criadas em CRe, e a outra metade em CNo, resultando em 14 tratamentos com cinco repetições de 15 aves. O OED foi adicionado pela manhã, na proporção de 1/4 do consumo diário da dieta, e, na parte da tarde, o fornecimento foi à vontade. Na fase pré-inicial, a inclusão de 0,015 e 0,026% de OED melhorou o consumo de ração e o ganho de peso, respectivamente. A inclusão de 0,031% de OED melhorou a conversão alimentar dos frangos de um a 21 dias. O OED promoveu maior peso de carcaça de aves alojadas em CNo, maiores pesos de coxa, sobrecoxa e rendimento de sobrecoxa de frangos criados em CRe. O OED melhorou o desempenho de frangos alojados sob condições de CRe.

The effect of essential fennel oil (EFO) as an alternative to antimicrobials in the diet of broiler chickens allotted on two type of new (LNo) and recycled (LRe) litter was evaluated. 1,050 birds were housed and adopted a completely randomized design in which from 1 to 21 days the birds were housed only LNo, with seven treatments and 10 replicates of 15 birds: T1 = positive control diet (PC) with antimicrobials (AM), T2 = negative control diet (NC) without AM and EFO, T3 = NC + 0.004% EFO, T4 = NC + 0.008% EFO, T5 = NC + 0.016% EFO T6 = NC + 0.032% EFO and T7 = NC + 0.064% EFO. From 22 to 42 days half of the birds housed in LRe and half continued in LNo, resulting in 14 treatments with five replicates of 15 birds. The EFO was added in the morning, at a ratio of 1/4 of the daily diet and in the afternoon the supply was at ease. In the pre-initial inclusion of 0.015 and 0.026% of EFO, feed intake and weight gain improved, respectively. The inclusion of 0.031% of EFO improved feed conversion of broilers from 1 to 21 days. The EFO promoted higher carcass in birds housed in LNo, higher drumstick weight, and thigh and drumstick yield for broilers reared in LRe. EFO improved the performance of chickens accommodated under LRe.